6-shogaol attenuates H2O2-induced oxidative stress via upregulation of Nrf2-mediated γ-glutamylcysteine synthetase and heme oxygenase expression in HepG2 cells

Homocysteine Induces Heme Oxygenase-1 Expression via Transcription Factor Nrf2 Activation in HepG2 Cells

Background: Elevated level of plasma homocysteine has been related to various diseases. Patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. We hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. Also, the cellular response designed to combat oxidative stress is primarily controlled by the transcripti...

homocysteine induces heme oxygenase-1 expression via transcription factor nrf2 activation in hepg2 cells

background: elevated level of plasma homocysteine has been related to various diseases. patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. we hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. also, the cellular response designed to combat oxidative stress is primarily controlled by the transcripti...

Monocytic Cells Is Mediated via Nrf2 and Oxygenase-1 Expression in Human Lipopolysaccharide-Induced Heme

Homocysteine induces heme oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 cell.

BACKGROUND Elevated level of plasma homocysteine has been related to various diseases. Patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. We hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. Also, the cellular response designed to combat oxidative stress is primarily controlled by the transcriptio...

eckol enhances heme oxygenase-1 expression through activation of Nrf2/JNK pathway in HepG2 cells.

Eckol isolated from Ecklonia stolonifera was previously reported to exhibit cytoprotective activity with its intrinsic antioxidant activity in in vitro studies. In this study, we characterized the mechanism underlying the eckol-mediated the expression of heme oxygenase-1 (HO-1). Eckol suppressed the production of intracellular reactive oxygen species and increased glutathione level in HepG2 cel...